Evidence of macroscopically entangled protons in a mixed isotope crystal of KH(p)D(1-p)CO3.

Where are protons and deuterons in KH p D 1 − p CO 3 ? A neutron diffraction study

Dmd057265 954..962

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVSCRF38), a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist. In an attempt to suppress O-demethylation of NVSCRF38 without losing activity against the CRF1 receptor, the protons at the...

Macroscopic entanglement of many-magnon states

Abstract We study macroscopic entanglement of various pure states of a one-dimensional N -spin system with N ≫ 1. Here, a quantum state is said to be macroscopically entangled if it is a superposition of macroscopically distinct states. To judge whether such superposition is hidden in a general state, we use an essentially unique index p: A pure state is macroscopically entangled if p = 2, wher...

Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.

Deuterium isotope effects were evaluated as a strategy to optimize the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole (NVS-CRF38), a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist. In an attempt to suppress O-demethylation of NVS-CRF38 without losing activity against the CRF1 receptor, the protons at ...

Kinetic isotope effects for fast deuterium and proton exchange rates.

By monitoring the effect of deuterium decoupling on the decay of transverse (15)N magnetization in D-(15)N spin pairs during multiple-refocusing echo sequences, we have determined fast D-D exchange rates kD and compared them with fast H-H exchange rates kH in tryptophan to determine the kinetic isotope effect as a function of pH and temperature.